This course explores the classical topics of information systems (IS) organized into five domains such as architecture/infrastructure, enterprise platforms, data management, analysis and decision support, communication, collaboration and digital media. In order to enhance the identity and legitimacy of IS in business we build strong connections with business and economic studies throughout the course, especially on how IS creates value in the digital age. The course is built upon the concept of digital innovation as a fundamental powerful organizing concept (FPC) which allows a variety of teaching styles and topical emphases for the IS domain. We present three types of innovation (i.e., process, product, and business model innovation), and four stages for the overall innovation process (i.e., discovery, development, diffusion, and impact). The course also intends to review the current research dilemmas and theoretical discussions of the IS field. Not only the traditional perspective-centered approach of theorizing is presented but also the more holistic, process oriented theories which are rooted in practice. While the objective is not to provide a general “theories of everything” for digital innovation, throughout the course we provide a diverse menu to serve as a discussion framework for Ph.D. students.